Cyto-Histopathological methods are refers to the study and  examination of tissues in order to study the manifestations of diseases. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the tissues has been processed for histological sections. In contrast, cytopathology examines free cells or tissue micro-fragments in order to give the correct diagnosis for prescription of the appropriate medication.

After the tissues preparation, the histological slides are examined under a microscope by a pathologist, a medically qualified specialist who has completed a recognised training program. This medical diagnosis is formulated as a pathology report describing the histological findings and the opinion of the pathologist. In the case of cancer (the most recognised pathology request this study), this represents the tissue diagnosis required for most treatment protocols.